Endocrine Abstracts

Introduction: Over the last few years, there are some studies that suggests a close connection between Nonalcoholic Liver Disease (NAFLD) and increased cardiovascular (CV) risk in population with obesity. Indeed, these two conditions share common drivers, most notably insulin resistance and other elements of the metabolic syndrome. Notwithstanding the above, this affirmation does not have solid scientific evidence. The proliferation of Vasa Vasorum (VV) in the adventitial laye...

Recent progress in surgical technology has resulted in new techniques as transoral endoscopic thyroidectomy (TOETVA) that is an option for patients’ cosmetic requests. We evaluated patients with thyroid cancer who underwent thyroidectomy by TOETVA approach and their follow-up. Retrospective study, 5 patients were included, Bethesda classification in FNAC resulted: 2 patients with VI category (CAT), 2: V CAT and 1: III CAT. All patients were operated by TOETVA between 2020...

Introduction: Gestational diabetes mellitus (GDM) is the metabolic disorder most frequently associated with pregnancy, presenting important maternal and fetal implications. Strict glycemic control through lifestyle measures and/or pharmacotherapy is essential to achieve adequate obstetric-perinatal results. The objective of this study is to compare baseline characteristics and perinatal results in patients diagnosed with GDM after performing oral glucose tolerance test (OGTT) ...

Objectives: MCL-1 and PD-L1 proteins are related to carcinogenesis mechanisms in differentiated thyroid carcinoma (DTC). Tumor antigens stimulate the expression of PD-1 in immune cells, which binds to PD-L1 of tumor cells, inducing immune escape from the tumor. MCL-1, an anti-apoptotic member of the BCL-2 family and has a high oncogenic potential. The relationship of these markers with prognosis in DTC remains unknown. We aim to evaluate the clinical utility of immunohistochem...

Objectives: BRAFV600E mutation is present in 50% of aggressive papillary thyroid carcinoma(PTC). TERT promoter (pTERT) mutations (C228T, C250T) are related to cancer growth and reduced overall- and disease-free survivals in differentiated thyroid carcinomas(DTC). We report a patient with an extremely aggressive PTC presenting in the primary lesion two pTERT mutations (C228T and C250T), and absence of BRAFV600E.<p class="abstext"...

Objectives: The angiotensin-converting enzyme (ACE1) gene is one of the most studied genes in the pathogenesis of type II diabetes (T2DM) and cardiovascular disease. However, in the context of exerciSemodels in T2DM, they are not yet fully understood. We intended to characterize the genetic profile of individuals with T2DM from an inter-individual point of view using prognostic markers and cardiovascular risk. On the other hand, relate it with the profile obtained wit...

Heterozygotes carrying CYP21A2 gene mutations are found in 5-10% of the general population in Mediterranean countries. Accumulating data suggest a survival advantage of this population, despite the fact that carriers of two mutations suffer from either classical or non-classical congenital adrenal hyperplasia (NC-CAH), an entity with increased mortality. In an attempt to elaborate on this issue we evaluated females of reproductive age with CYP21A2 heterozygocity (HET). We have...

Hypoparathyroidism is an endocrine deficiency whose substitution treatment with PTH 1-84 is only available in compassionate use in Argentina. There is a subgroup of patients in which the conventional therapy with calcium, calcitriol, phosphorous chelators, magnesium and diuretics does not reach an adequate clinical and/or biochemical compensation. Although teriparatide (PTH 1-34) is not approved for patients with hypoparathyroidism, it is a plausible therapeutic resource.<...

Aim: Epicardial adipose tissue (EAT) has important physiologic functions, nonetheless, excessive EAT leads to a proinflammatory state with adverse effects on the myocardium. EAT has also been associated with adverse outcomes in chronic kidney disease (CKD) patients. We think that visceral adipose tissue (VAT) and organ-specific ectopic fat plays an important role in cardiorenal dysfunction. The aim of our study is to analyse the relationship between EAT and the risk of develop...

The mutations of succinate dehydrogenase subunits (SDHA, SDHB, SDHC, SDHD) are linked with a predisposition to develop pheochromocytoma and paraganglioma, often in diferent locations of the body. With greater acces to genetic tests, current estimations suggest that 40-50% of pheocromocytoma and paraganglioma cases are inherited and half of them are due to SDH mutations. These mutations can be associated with other tumours like renal carcinomas, gastrointestinal stroma tumours ...